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Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development

Authors Cascone R, Carlucci A, Pierdiluca M, Santini M, Fiorelli A

Received 14 March 2017

Accepted for publication 29 June 2017

Published 10 October 2017 Volume 2017:8 Pages 161—167


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Pan-Chyr Yang

Roberto Cascone, Annalisa Carlucci, Matteo Pierdiluca, Mario Santini, Alfonso Fiorelli

Thoracic Surgery Unit, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, Italy

Abstract: Soluble major histocompatibility complex class I polypeptide-related sequence A (sMICA) is a useful marker in surveillance of lung cancer. High serum sMICA level in patients with non-small-cell lung cancer (NSCLC) seems to be a poor prognostic factor being correlated with poor differentiation and advanced stage. However, the low specificity limits its role as a single prognostic marker of NSCLC, but its evaluation, in addition to standard serum markers, could improve the staging of NSCLC. Despite promising, all current studies are insufficient to assess the real efficiency of sMICA as a prognostic marker of NSCLC, and hence, future studies are required to validate it.

Keywords: NSCLC, MICA, MICB, prognostic factor

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