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Prognosis of patients with neuroendocrine tumor: a SEER database analysis

Authors Man D, Wu J, Shen Z, Zhu X

Received 22 May 2018

Accepted for publication 30 August 2018

Published 13 November 2018 Volume 2018:10 Pages 5629—5638

DOI https://doi.org/10.2147/CMAR.S174907

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Professor Nakshatri


Da Man,1,* Jingjing Wu,2,3,* Zhan Shen,1 Xiaoyi Zhu1

1Department of Colorectal Surgery, Shulan (Hangzhou) Hospital, Hangzhou, China; 2State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; 3Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China

*These authors contributed equally to this work

Background:
Neuroendocrine tumors (NETs) are a group of heterogeneous cancers arising from a variety of anatomic sites. Their incidence has increased in recent years. This study aimed to analyze the prognosis of NETs originating from different anatomic sites.
Methods:
We identified 73,782 patients diagnosed with NETs from the Surveillance Epidemiology and Ends Results (SEER) database from 1973 to 2014. Clinical data were compared between patients with different primary tumor sites using the chi-squared test. Differences in survival among NET patients with different tumor sites were compared by Kaplan–Meier analysis. Cox proportional hazard models were performed to identify the prognostic factors of overall survival.
Results: In this cohort, the lung/bronchus was the most common site of NETs, accounting for 30.6%, followed by the small intestine (22.2%), rectum (16.2%), colon (13.4%), pancreas (10.8%), and stomach (6.8%). Totally, 73,782 patients were selected for this cohort from 1973 to 2014. The median survival duration was 41 months. The 1-, 3-, 5-, and 10-year overall survival rates for patients with NETs were 72.8%, 52.7%, 39.4%, and 18.1%, respectively. Patients with NETs located in the rectum had the best prognosis, followed by those with NETs in the small intestine (HR, 1.660, 95% CI, 1.579, 1.744), lung/bronchus (HR, 1.786, 95% CI, 1.703, 1.874), stomach (HR, 1.865, 95% CI, 1.755, 1.982), and colon (HR, 1.896, 95% CI, 1.799, 1.999). Patients with NETs in the pancreas had the highest risk of mortality (HR, 2.034, 95% CI, 1.925, 2.148).
Conclusion: Significant differences in survival were found among various primary tumor sites. NETs in the rectum had the best prognosis, while those in the pancreas had the worst. Primary tumor sites might be one of the most useful outcome predictors in patients with NETs.

Keywords: neuroendocrine tumor, SEER program, survival analysis, primary tumor sites

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