Associate Editor: Dr Harikrishna Nakshatri
Dr. Nakshatri’s research interests are on heterogeneity in normal breast, the mechanisms of anti-estrogen resistance and metastasis in breast cancer. Ongoing research in his lab includes elucidating the mechanisms by which the serine/threonine kinase AKT alters estrogen signaling and confers anti-estrogen resistance. His laboratory has identified and commercialized biomarkers that may predict response to anti-estrogen therapy. His laboratory was the first to demonstrate constitutive activation of NF-kappaB in a subset of breast cancer. Activated NF-kappaB confers chemotherapy resistance and enhances metastasis. His laboratory is also investigating the mechanisms of organ-specific metastasis and the role of cancer stem cells in chemoresistance and metastasis. Using the normal breast tissue from Susan G. Komen for the Cure Tissue Bank, his group has shown ethnicity-dependent and ethnicity-independent heterogeneity in normal breast. His group has also established a culturing method to grow tumors, and tumor adjacent-normal, and metastasis to genomically characterize tumors/metastasis at single cell level. NIH, Department of Defense, American Cancer Society, Susan G. Komen for Cure, Department of Veterans Affairs and other private foundations funded his research. He is the author or co-author of >120 publications with >12,500 citations. He has served/serving in scientific review committees of NIH, Department of Defense, Italian Association for Cancer Research, and Susan G. Komen for Cure. He is one among 52 breast cancer researchers who serve as Susan G. Komen Scholars (2010-2020). He is currently a member of the NIH Cancer Molecular Pathobiology Study Section. He is also in the editorial boards of scientific journals and an Associate Editor of Cancer Research. He has trained over 20 post-doctoral fellows, surgical residents, and medical students. In his role as the Associate Director of Education at the Indiana University Simon Cancer Center (IUSCC), he is responsible for developing educational activities of the cancer center and a training program in cancer biology.