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Primary clear cell adenocarcinoma of the pancreas: a case report and literature update

Authors Sun PJ, Yu YH, Cui XJ

Received 8 August 2018

Accepted for publication 31 October 2018

Published 16 November 2018 Volume 2018:11 Pages 8197—8200

DOI https://doi.org/10.2147/OTT.S183054

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Tohru Yamada


Pi-Jiang Sun,1 Yan-Hua Yu,2 Xi-Jun Cui1

1Department of Hepatobiliary Surgery, Weihai Central Hospital, Weihai 264400, Shandong Province, People’s Republic of China; 2Department of Dermatology, Weihai Central Hospital, Weihai 264400, Shandong Province, People’s Republic of China

Abstract: Primary clear cell carcinoma of pancreas is extremely rare. We present a case of a 64-year-old male with a mass in the distal body and tail of the pancreas. He underwent a distal pancreatectomy. The histopathology of tumor cells showed features with abundant clear cytoplasm and prominent cell boundaries. Immunohistochemical analysis of neoplastic cells showed reactions to antibodies against cytokeratin-7 and showed no reactions to antibodies against hepatocyte nuclear factor-1β, carbonic anhydrase 9, synaptophysin, and chromogranin A. The patient was subsequently diagnosed with a primary clear cell carcinoma of the pancreas. This is the first time we have encountered it. We report this rare case and update the current literature of this tumor.

Keywords: clear cell carcinoma, pancreas, rare tumor

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