Prevalence of metabolic syndrome and its associated factors in Chinese patients with ankylosing spondylitis
Received 11 December 2018
Accepted for publication 28 February 2019
Published 11 April 2019 Volume 2019:12 Pages 477—484
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 4
Editor who approved publication: Dr Konstantinos Tziomalos
Meng Liu, Yukai Huang, Zhengping Huang, Qidang Huang, Xin Guo, Yunqing Wang, Weiming Deng, Zhixiang Huang, Tianwang Li
Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, People’s Republic of China
Purpose: We assessed the prevalence of metabolic syndrome (MetS) and associated factors in mainland Chinese patients with ankylosing spondylitis (AS).
Patients and methods: A retrospective study was conducted in 117 AS patients and 117 age- and sex-matched healthy controls. Parameters of MetS based on the criteria established by the Chinese Diabetes Society in 2013 were tabulated. Demographic features, laboratory data, and clinical characteristics were also collected. Independent factors correlated with MetS in AS patients were identified by backward stepwise multivariate analysis.
Results: The prevalence of MetS was higher in AS patients than in healthy controls (P= 0.026). AS patients also had higher blood pressure and fasting serum glucose levels, but generally lower serum lipid levels. AS patients with and without MetS had no distinct differences in disease duration, medication usage, disease activity, or biomarkers of inflammation. Multivariable logistic regression analysis showed that hyperuricemia (odds ratio [OR] = 2.385, 95% confidence interval [95% CI] = 1.019–5.582, P= 0.045) and high body mass index (BMI, OR = 5.165; 95% CI = 1.935–13.787, P=0.001) were independent factors for MetS in AS patients.
Conclusion: Chinese AS patients living in the mainland have an increased risk of developing MetS. Hyperuricemia and high BMI are predictors of MetS in AS patients.
Keywords: ankylosing spondylitis, metabolic syndrome, prevalence, hyperuricemia
Corrigendum for this paper has been published.
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