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Pragmatic and Observational Research

ISSN: 1179-7266

Editor-in-Chief: Professor David Price

An international, peer reviewed, open access journal that publishes data from studies designed to reflect more closely medical interventions in real-world clinical practice compared with classical randomized controlled trials (RCTs).

Classical RCTs are designed to maximise internal validity and to establish an unequivocal cause-and-effect relationship between an intervention and an outcome. Classical RCT populations represent only minority groups of real-life patients and are thus limited in their extent. Complementary data from studies designed to reflect more closely the nature of real-world patients and medicines usage are required to inform guidelines and extrapolate research findings across the broad heterogeneous patient populations encountered in everyday clinical practice.

The journal publishes data from prospective and retrospective studies designed to evaluate outcomes associated with real-world clinical practice. Dissemination of this data and the techniques and approaches used to optimise real-world modeling allows outcome validation and improved standards and collaboration in this growing area of research.

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE).

We are currently seeking expressions of interest for Editorial Board members for this journal.
Please send your CV and a one-page vision statement detailing your overall objectives for the journal to Emi Kirilova - [email protected]


Latest articles:

- 5 records -

Using Claims Data to Predict Pre-Operative BMI Among Bariatric Surgery Patients: Development of the BMI Before Bariatric Surgery Scoring System (B3S3)

Wong J, Li X, Arterburn DE, Li D, Messenger-Jones E, Wang R, Toh S

Pragmatic and Observational Research 2024, 15:65-78

Published Date: 27 March 2024

Trends in Systemic Glucocorticoid Utilization in the United Kingdom from 1990 to 2019: A Population-Based, Serial Cross-Sectional Analysis

Menzies-Gow AN, Tran TN, Stanley B, Carter VA, Smolen JS, Bourdin A, Fitzgerald JM, Raine T, Chapaneri J, Emmanuel B, Jackson DJ, Price DB

Pragmatic and Observational Research 2024, 15:53-64

Published Date: 15 March 2024

Difficult-To-Treat and Severe Asthma: Can Real-World Studies On Effectiveness of Biological Treatments Change the Lives of Patients?

Pelaia C, Giacalone A, Ippolito G, Pastore D, Maglio A, Piazzetta GL, Lobello N, Lombardo N, Vatrella A, Pelaia G

Pragmatic and Observational Research 2024, 15:45-51

Published Date: 11 March 2024

Obesity Paradox in Heart Failure with Mildly Reduced Ejection Fraction

Reinhardt M, Schupp T, Abumayyaleh M, Lau F, Schmitt A, Abel N, Akin M, Rusnak J, Akin I, Behnes M

Pragmatic and Observational Research 2024, 15:31-43

Published Date: 5 March 2024

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