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Pragmatic and Observational Research

ISSN: 1179-7266

Editor-in-Chief: Professor David Price

An international, peer reviewed, open access journal that publishes data from studies designed to reflect more closely medical interventions in real-world clinical practice compared with classical randomized controlled trials (RCTs).

Classical RCTs are designed to maximise internal validity and to establish an unequivocal cause-and-effect relationship between an intervention and an outcome. Classical RCT populations represent only minority groups of real-life patients and are thus limited in their extent. Complementary data from studies designed to reflect more closely the nature of real-world patients and medicines usage are required to inform guidelines and extrapolate research findings across the broad heterogeneous patient populations encountered in everyday clinical practice.

The journal publishes data from prospective and retrospective studies designed to evaluate outcomes associated with real-world clinical practice. Dissemination of this data and the techniques and approaches used to optimise real-world modeling allows outcome validation and improved standards and collaboration in this growing area of research.

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE).

We are currently seeking expressions of interest for Editorial Board members this journal.
Please send your CV and a one-page vision statement detailing your overall objectives for the journal to Emi Kirilova - [email protected]


Latest articles:

- 5 records -

Data-Resource Profile: United Kingdom Optimum Patient Care Research Database

Lynam A, Curtis C, Stanley B, Heatley H, Worthington C, Roberts EJ, Price C, Carter V, Dennis J, McGovern A, Price D

Pragmatic and Observational Research 2023, 14:39-49

Published Date: 27 April 2023

Administrative Databases and Diagnostic Therapeutic and Assistance Paths -PDTA- in the Monitoring Treatment of Rheumatoid Arthritis: The Experience of ATS Pavia

Bruno GM, Valentino MC, Brunetti A, Di Matteo S, Begovic I, Croce E, Sakellariou G, Bugatti S, Perotti P, Vecchio S, Migliazza S, Langella R, Colombo GL

Pragmatic and Observational Research 2023, 14:29-38

Published Date: 19 April 2023

Alignment of Physician-Stated vs Clinically Derived Reference Fibrosis Score in Patients with Non-Alcoholic Steatohepatitis: A Real-World European Survey

Anstee QM, Hallsworth K, Lynch N, Hauvespre A, Mansour E, Kozma S, Bottomley J, Milligan G, Piercy J, Higgins V

Pragmatic and Observational Research 2023, 14:13-27

Published Date: 24 February 2023

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