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Olfactory dysfunction in Alzheimer’s disease

Authors Zou Y, Lu D, Liu L, Zhang H, Zhou Y

Received 23 January 2016

Accepted for publication 24 February 2016

Published 15 April 2016 Volume 2016:12 Pages 869—875

DOI https://doi.org/10.2147/NDT.S104886

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Papan Thaipisuttikul

Peer reviewer comments 2

Editor who approved publication: Professor Wai Kwong Tang


Yong-ming Zou, Da Lu, Li-ping Liu, Hui-hong Zhang, Yu-ying Zhou

Department of Neurology, Tianjin Huanhu Hospital, Tianjin, People’s Republic of China

Abstract: Alzheimer’s disease (AD) is a common neurodegenerative disorder with the earliest clinical symptom of olfactory dysfunction, which is a potential clinical marker for AD severity and progression. However, many questions remain unanswered. This article reviews relevant research on olfactory dysfunction in AD and evaluates the predictive value of olfactory dysfunction for the epidemiological, pathophysiological, and clinical features of AD, as well as for the conversion of cognitive impairment to AD. We summarize problems of existing studies and provide a useful reference for further studies in AD olfactory dysfunction and for clinical applications of olfactory testing.

Keywords: olfactory dysfunction, Alzheimer’s disease, olfactory testing, progress

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