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Neural correlates of delusional infestation responding to aripiprazole monotherapy: a case report

Authors Ponson L, Andersson F, El-Hage W

Received 23 September 2014

Accepted for publication 18 November 2014

Published 2 February 2015 Volume 2015:11 Pages 257—261

DOI https://doi.org/10.2147/NDT.S74786

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder


Laura Ponson,1,2 Frédéric Andersson,1 Wissam El-Hage1,2

1Université François-Rabelais de Tours, Inserm, Imagerie et Cerveau UMR U930, Tours, France, 2CHRU de Tours, Clinique Psychiatrique Universitaire, Tours, France

Background: The pathophysiology and appropriate pharmacological interventions for delusional infestation remain unknown.
Case presentation: Here, we report a case of primary delusional infestation successfully treated with aripiprazole. We performed functional magnetic resonance imaging (fMRI) to investigate brain structures and functional modifications. Before antipsychotic treatment, pre- versus post-treatment fMRI images revealed a marked increase in brain activation in the supplementary motor area (SMA).
Conclusion: Our results highlight the efficacy and safety of aripiprazole in the treatment of delusional infestation and the possible role of SMA dysfunction in delusional infestation. Indeed, our results suggest that psychiatric improvement of delusional infestation is associated with normalization of brain activity, particularly in the SMA.

Keywords: supplementary motor area, antipsychotics, fMRI

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