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Molecular mechanisms of cisplatin resistance in cervical cancer

Authors Zhu H, Luo H, Zhang W, Shen Z, Hu X, Zhu X

Received 14 February 2016

Accepted for publication 10 March 2016

Published 7 June 2016 Volume 2016:10 Pages 1885—1895

DOI https://doi.org/10.2147/DDDT.S106412

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ankur Sharma

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Wei Duan


Haiyan Zhu, Hui Luo, Wenwen Zhang, Zhaojun Shen, Xiaoli Hu, Xueqiong Zhu

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China

Abstract: Patients with advanced or recurrent cervical cancer have poor prognosis, and their 1-year survival is only 10%–20%. Chemotherapy is considered as the standard treatment for patients with advanced or recurrent cervical cancer, and cisplatin appears to treat the disease effectively. However, resistance to cisplatin may develop, thus substantially compromising the efficacy of cisplatin to treat advanced or recurrent cervical cancer. In this article, we systematically review the recent literature and summarize the recent advances in our understanding of the molecular mechanisms underlying cisplatin resistance in cervical cancer.

Keywords: cisplatin, epithelial–mesenchymal transition, microRNA, molecular mechanism, resistance

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