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Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives

Authors Zomer H, Vidane A, Gonçalves N, Ambrosio C

Received 6 May 2015

Accepted for publication 26 June 2015

Published 28 September 2015 Volume 2015:8 Pages 125—134

DOI https://doi.org/10.2147/SCCAA.S88036

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Zhifang Qiu

Peer reviewer comments 4

Editor who approved publication: Dr Bernard Binetruy

Helena D Zomer,1 Atanásio S Vidane,1 Natalia N Gonçalves,1 Carlos E Ambrósio2

1Department of Surgery, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil; 2Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil

Abstract: Mesenchymal stem cells have awakened a great deal of interest in regenerative medicine due to their plasticity, and immunomodulatory and anti-inflammatory properties. They are high-yield and can be acquired through noninvasive methods from adult tissues. Moreover, they are nontumorigenic and are the most widely studied. On the other hand, induced pluripotent stem (iPS) cells can be derived directly from adult cells through gene reprogramming. The new iPS technology avoids the embryo destruction or manipulation to generate pluripotent cells, therefore, are exempt from ethical implication surrounding embryonic stem cell use. The pre-differentiation of iPS cells ensures the safety of future approaches. Both mesenchymal stem cells and iPS cells can be used for autologous cell transplantations without the risk of immune rejection and represent a great opportunity for future alternative therapies. In this review we discussed the therapeutic perspectives using mesenchymal and iPS cells.

Keywords: cell transplantation, cell therapy, iPS, MSC

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