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Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage

Authors Alessio N, Santoro E, Squillaro T, Aprile D, Briccola M, Giubbini P, Marchesani R, Muoio MR, Lamberti M

Received 5 February 2019

Accepted for publication 10 July 2019

Published 18 December 2019 Volume 2019:12 Pages 49—59

DOI https://doi.org/10.2147/SCCAA.S204166

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Bernard Binetruy


Nicola Alessio,1,* Elisa Santoro,2,* Tiziana Squillaro,3 Domenico Aprile,1 Massimo Briccola,4 Paolo Giubbini,4 Raffaella Marchesani,4 Maria Rosaria Muoio,2 Monica Lamberti2

1Department of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2Department of Experimental Medicine, Occupational Medicine Section, University of Campania "Luigi Vanvitelli", Naples, Italy; 3Department of Medical, Surgical, Neurological, Metabolic Sciences, and Aging, 2nd Division of Neurology, Center for Rare Diseases and InterUniversity Center for Research in Neurosciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; 4e-distribuzione SpA, Rome, Italy

*These authors contributed equally to this work

Correspondence: Nicola Alessio
Department of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania “Luigi Vanvitelli”, Naples, Napoli I-80138, Italy
Tel +39 081 5667585
Fax +39 081 5667547
Email nicola.alessio@yahoo.it

Monica Lamberti
Department of Experimental Medicine, Occupational Medicine Section, University of Campania “Luigi Vanvitelli”, Naples, Napoli I-80138, Italy
Tel +39 081 5667731
Email monica.lamberti@unicampania.it

Background: The ubiquitous diffusion of radiofrequency (RF) radiation across human living environments has attracted the attention of scientists. Though the adverse health effects of RF exposure remain debatable, it has been reported that the interaction of such radiation with biological macromolecular structures can be deleterious for stem cells, inducing impairment of their main functions involving self-renewal and differentiation.
Purpose: The purpose of this study was to determine whether exposure to RF of 169 megahertz (MHz) that is part of very high radiofrequency (VHF) range 30–300 MHz, could cause damage to stem cells by inducing senescence and loss of regenerative and DNA repair capacity.
Methods: The study was conducted on mesenchymal stromal cells (MSCs) containing a subpopulation of stem cells. The MSCs were exposed to RFs of 169 MHz administered via an open meter 2G “Smart Meter” for different durations of time.
Result: We did not observe modifications in MSC biology as a result of the RF exposure conducted in our experiments.
Conclusion: We concluded that MSCs are insensitive to RF radiation exposure at 169 MHz for various time intervals, including longer durations.

Keywords: 169 MHz, stem cell, senescence, CFU

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