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Low-density lipoprotein receptor-related protein in metalloproteinase-mediated pathologies: recent insights

Authors Emonard H, Marbaix E

Received 30 December 2014

Accepted for publication 14 January 2015

Published 11 February 2015 Volume 2015:2 Pages 9—18

DOI https://doi.org/10.2147/MNM.S63616

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor William Parks

Hervé Emonard,1 Etienne Marbaix2

1“Matrice Extracellulaire et Dynamique Cellulaire” Unit, Centre National de Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 7369, Université de Reims Champagne-Ardenne, Laboratoire SiRMa, Reims, France; 2Institut de Duve, Université catholique de Louvain, Bruxelles, Belgique

Abstract: Low-density lipoprotein receptor-related protein (LRP)-1, LRP-1b, LRP-2, LRP-5, and LRP-6 mediate the endocytosis of metalloproteinases and inhibitors and/or promote the expression of metalloproteinases. These properties confer important and complex roles in the development of pathologies related to an intense proteolytic degradation of the cellular microenvironment. The cell surface levels of the identified endocytic receptors, LRP-1, LRP-1b, and LRP-2, are themselves regulated by metalloproteinases. The released extra- and intracellular domains may also exert functions in these pathologies.

Keywords: LRP, MMP, ADAM, ADAMTS
 

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