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Invasive atypical thymic carcinoid: three case reports and literature review

Authors Zhu S, Wang Z, Liu W, Zong S, Li B

Received 1 April 2016

Accepted for publication 23 August 2016

Published 11 October 2016 Volume 2016:9 Pages 6171—6176

DOI https://doi.org/10.2147/OTT.S109693

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 3

Editor who approved publication: Professor Min Li


Shan Zhu,1,2 Zhong-Tang Wang,2 Wen-Zhi Liu,2,3 Shi-Xiang Zong,4 Bao-Sheng Li2

1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, 2Department of Radiotherapy, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, 3Department of Clinical Oncology, Taian Central Hospital, Taian, 4Jinan Hospital, Jinan, Shandong Province, People’s Republic of China

Abstract: Atypical thymic carcinoid is an extremely rare thymic neuroendocrine tumor derived from the neuroendocrine system. The aims of this paper were to investigate the clinical features of atypical thymic carcinoid and collate information and experience to improve the diagnosis and treatment of this disease. We describe three cases of atypical carcinoid of the thymus; clinical features, pathological data, treatment modalities, and short-term patient outcomes were summarized and analyzed. The initial clinical symptoms and signs of all three patients were nonspecific and an anterior mediastinal mass was found in each patient on chest computed tomography scan. All three patients underwent surgical resection (total thymectomy and complete excision of the tumor), followed by postoperative radiotherapy, with or without chemotherapy. The diagnoses of three patients were confirmed by pathological and immunohistochemical evaluation. We also present a review of the literature to collate as much information as possible and provide a reference for proper diagnosis and treatment of atypical thyroid carcinoid.

Keywords: thymic tumors, neuroendocrine tumor, carcinoid, atypical carcinoid, atypical thymic carcinoid

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