Back to Journals » Lung Cancer: Targets and Therapy » Volume 7

High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells

Authors Tian H, Li X, Jiang W, Lv C, Sun W, Huang C, Chen R

Received 18 June 2015

Accepted for publication 25 September 2015

Published 2 May 2016 Volume 2016:7 Pages 53—61


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Pingping Chen

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Pan-Chyr Yang

He Tian,1 Xing Li,2 Wenli Jiang,3 Cuiting Lv,3 Weizhang Sun,4 Caiguo Huang,3 Ruohua Chen,5

1Department of Pediatrics of Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China; 2Department of Gynecology and Obstetrics of Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China; 3Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, People's Republic of China; 4PET Center, Chengdu Military Command Region General Hospital, Chengdu, People's Republic of China; 5VIP Clinic of Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China

Abstract: AKR1C1 is a member of the AKR1C family, which not only plays an important role in hormone metabolism but is believed to be involved in carcinogen metabolism. Our previous study demonstrated that AKR1C1 was highly expressed in lung tumor tissues as compared with the tumor-adjacent tissues. Small-cell lung cancer (SCLC) is a special type of lung cancer. Surgical treatment of SCLC is usually difficult due to the high degree of malignancy and early metastasis, and difficulty in obtaining clinical specimens. There is not much basic or clinical research on SCLC in the People's Republic of China even in recent years. To investigate the mechanism of AKR1C1 in the pathogenesis of SCLC, the present study used H446 cell line to see whether AKR1C1 could affect the proliferation or migration of SCLC cells, and used a lentivirus to build the AKR1C1 overexpression and under-expression cell lines. The results indicated that AKR1C1 was an important inducement in the proliferation and migration of H446 cells. AKR1C1 promoted cell proliferation and played a vital role in the migration of SCLC cells. These results were also verified in nude mice in vivo. In conclusion, AKR1C1 plays an important role in the development and progression of SCLC and may represent an independent biomarker for assessment of the primary prognosis and therapy of SCLC.

Keywords: AKR1C1, migration, NCI-H446, proliferation, small-cell lung cancer (SCLC) 

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Readers of this article also read:

miRNA-21 as a novel therapeutic target in lung cancer

Markou A, Zavridou M, Lianidou ES

Lung Cancer: Targets and Therapy 2016, 7:19-27

Published Date: 2 March 2016

HSP90 as a novel molecular target in non-small-cell lung cancer

Esfahani K, Cohen V

Lung Cancer: Targets and Therapy 2016, 7:11-17

Published Date: 1 March 2016

Oncolytic viral therapy for pancreatic cancer: current research and future directions

Ady JW, Heffner J, Klein E, Fong Y

Oncolytic Virotherapy 2014, 3:35-46

Published Date: 17 February 2014

How to reduce your cancer risk: mechanisms and myths

Nahleh Z, Bhatti NS, Mal M

International Journal of General Medicine 2011, 4:277-287

Published Date: 8 April 2011