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Fragmentation of Rest/Activity Patterns in Community-Based Elderly Individuals Predicts Incident Heart Failure

Authors Gao L, Lim ASP, Wong PM, Gaba A, Cui L, Yu L, Buchman AS, Bennett DA, Hu K, Li P

Received 13 March 2020

Accepted for publication 11 May 2020

Published 27 May 2020 Volume 2020:12 Pages 299—307

DOI https://doi.org/10.2147/NSS.S253757

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Sutapa Mukherjee


Lei Gao,1,2 Andrew SP Lim,3 Patricia M Wong,4 Arlen Gaba,2 Longchang Cui,2 Lei Yu,5 Aron S Buchman,5 David A Bennett,5 Kun Hu,2,6 Peng Li2,6

1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; 2Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115, USA; 3Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, USA; 4Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA; 5Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA; 6Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA

Correspondence: Lei Gao
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Tel +1 617 888-2941
Fax +1 617 732-7337
Email lgao@mgh.harvard.edu
Peng Li
Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115, USA
Tel +1 617 278-0061
Fax +1 617 732-7337
Email pli9@bwh.harvard.edu

Study Objectives: Heart failure has previously been linked to sleep disorders that are often associated with frequent disturbances to human rest/activity patterns. We tested whether fragmentation of sustained rest/activity patterns derived from actigraphic recordings at baseline predicts incident heart failure in community-based elderly individuals.
Methods: We studied 1099 community-based elderly adults participating in the Rush Memory and Aging Project who had baseline motor activity monitoring up to 11 days and were followed annually for up to 14 years. Fragmentation was assessed using previously validated indexes, derived from the probability of transitions once sustained rest or activity has been established. Heart failure was recorded via a clinical interview during the annual follow-up. Cox proportional hazards models were constructed to examine the relationship between rest fragmentation index and incident heart failure. Covariates grouped in terms of demographics, lifestyle factors and co-morbidities and cardiovascular risk factors/diseases were included.
Results: Increased rest fragmentation (but not activity fragmentation) was associated with higher risk for incident heart failure. Specifically, a subject with a rest fragmentation at the 90th percentile showed a 57% increased risk of developing incident heart failure compared to a subject at the 10th percentile in this cohort. This effect was equivalent to that of being over a decade older. These observations were consistent after adjusting for all covariates.
Conclusion: Increased rest fragmentation, a potential surrogate for sleep fragmentation, is independently associated with a higher risk of developing heart failure in community-based elderly adults during up to 14 years of follow-up. Further work is required to examine the specific contributions from daytime napping versus nighttime sleep periods in the elderly, as well as the underlying autonomic and cardio-dynamic pathways that may explain the effects on heart function.

Keywords: sleep fragmentation, heart failure, mobile health, unobtrusive monitoring

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