Eye and Brain

Transcription Factors in Eye Development and Disease

In the human and mouse genomes there are more than 1800 DNA-binding transcription factors. At least 1000 genes are required for the normal development of the eye. It is now established that several transcription factors are of crucial importance for the normal development of specific retinal cells and functions. However, less is known about the role of these transcription factors in eye diseases affecting the retina, the cornea, and other parts of the eye.