Back to Journals » International Journal of General Medicine » Volume 11

Evaluating the use of corticosteroids in preventing and treating bronchopulmonary dysplasia in preterm neonates

Authors Olaloko O, Mohammed R, Ojha U

Received 27 November 2017

Accepted for publication 21 February 2018

Published 3 July 2018 Volume 2018:11 Pages 265—274

DOI https://doi.org/10.2147/IJGM.S158184

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Oreoluwa Olaloko,1 Raihan Mohammed,1 Utkarsh Ojha2

1Faculty of Medicine, University of Cambridge, Cambridge, UK; 2Faculty of Medicine, Imperial College, London, UK

Abstract: Approximately 15 million babies worldwide are born premature, and complications of prematurity are one of the leading causes of death in neonates. Neonatal respiratory distress syndrome (NRDS) and bronchopulmonary dysplasia (BPD) are two of the most common and serious consequences of prematurity. Synthetic corticosteroids, including dexamethasone, have been central in efforts to treat and prevent BPD. There is strong evidence to show that prenatal corticosteroids reduce infant mortality and the incidence of NRDS, leading to their widespread use in obstetric units. However, data suggest that they are not as effective in reducing the incidence of BPD as NRDS, which may be due to the multifactorial pathogenesis of BPD. On the other hand, the use of postnatal corticosteroids in preterm infants is much more controversial. They have been shown to improve lung function and help in reducing the need for mechanical ventilation. These benefits, however, are associated with a range of adverse short- and long-term effects. This review will discuss the benefits and consequences of corticosteroids in treating BPD and will examine alternative treatments and future research that may improve the understanding of BPD and inform clinical practice.

Keywords: bronchopulmonary dysplasia, corticosteroids, preterm birth, prenatal, postnatal

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]