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Epoetin beta for the treatment of chemotherapy-induced anemia: an update

Authors Galli L, Ricci C, Egan C

Received 14 November 2014

Accepted for publication 30 January 2015

Published 5 March 2015 Volume 2015:8 Pages 583—591

DOI https://doi.org/10.2147/OTT.S77497

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Faris Farassati


Luca Galli,1 Clara Ricci,2 Colin Gerard Egan2

1Oncology Unit 2, University Hospital of Pisa, Pisa, Italy; 2Primula Multimedia SRL, Pisa, Italy

Abstract: Epoetin beta belongs to the class of erythropoiesis-stimulating agents (ESAs) that are currently available to treat anemic patients receiving chemotherapy. Chemotherapy-induced anemia affects a high percentage of cancer patients and, due to its negative effects on disease outcome and the patient’s quality of life, should be treated when first diagnosed. Initial trials with ESAs have shown efficacy in improving quality of life and reducing the need for blood transfusions in patients with chemotherapy-induced anemia. However, recent meta-analyses have provided conflicting data on the impact of ESAs on survival and tumor progression. Here we provide an overview of these recent data and review the role of epoetin beta in the treatment of chemotherapy-induced anemia over the past 20 years.

Keywords: epoetin beta, erythropoietin, chemotherapy, cancer, anemia, treatment

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