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Dynamic Monitoring of Hypothyroidism During Pregnancy [Letter]
Received 6 October 2023
Accepted for publication 23 October 2023
Published 26 October 2023 Volume 2023:15 Pages 1625—1626
DOI https://doi.org/10.2147/IJWH.S441682
Checked for plagiarism Yes
Editor who approved publication: Professor Elie Al-Chaer
Chenlin Pei, Yuelan Liu, Jingrui Huang
Department of Obstetrics, Xiangya Hospital Central South University, Changsha, People’s Republic of China
Correspondence: Jingrui Huang, Department of Obstetrics, Xiangya Hospital Central South University, 87 Xiangya Road, Changsha, 410008, People’s Republic of China, Email [email protected]; [email protected]
View the original paper by Dr Abadi and colleagues
A Response to Letter has been published for this article.
Dear editor
With great interest, we have read the research by Kidus Kebede Abadi et al about prevalence of hypothyroidism in pregnancy and its associations with adverse pregnancy outcomes among pregnant women in a general hospital.1 The purpose of this research is to determine the magnitude and pregnancy adverse outcomes associated with hypothyroidism among pregnant women having maternity services in a general hospital in Somalia. After rigorous experimental design and implementation, this study has shown a high prevalence of hypothyroidism during pregnancy at Daruxannan Hospital compared to previous studies around the world.
In this study, the authors used the standard 0.3–3.0 mIU/L for third trimester. The diagnosis of hypothyroidism in pregnancy is dynamic. In first and second trimesters, normal thyroid stimulating hormone has different ranges, which are usually 0.1–2.5 mIU/L and 0.2–3.0 mIU/L.2 Many studies have recommended the establishment of specific TSH reference ranges for each region.3 This study also needs to consider the proportion of abnormal thyroid stimulating hormone in late pregnancy had been already abnormal in first and second trimesters. This hypothyroidism may require intervention. Therefore, some of the adverse pregnancy outcomes in the study, such as hypertensive disorders of pregnancy and preterm birth, may be related to hypothyroidism in first and second trimesters rather than late pregnancy.
In general, this study helps to establish local thyroid stimulating hormone reference ranges. The management of hypothyroidism is required throughout pregnancy.
Acknowledgement
We thank Dr. Liangqun Xie for initial revision of the manuscript.
Data Sharing Statement
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
Author Contributions
All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.
Funding
This research was funded by the Natural Science Foundation of Hunan Province (2022JJ40789), the National Natural Science Foundation of China (82371700), the Scientific Research Project of Hunan Provincial Development and Reform Commission (2021212), the Scientific Research Project of Hunan Provincial Health Commission (202105022347), the Guangdong Provincial Basic and Applied Basic Research Foundation Committee’s Provincial Enterprise Alliance Project (2021A1515220159).
Disclosure
The authors declare no conflict of interest in this communication.
References
1. Abadi KK, Jama AH, Legesse AY, Gebremichael AK. Prevalence of hypothyroidism in pregnancy and its associations with adverse pregnancy outcomes among pregnant women in a General Hospital: a cross sectional study. Int J Womens Health. 2023;15:1481–1490. doi:10.2147/IJWH.S429611
2. Karavani G, Daoud-Sabag L, Chay C, Gillis D, Strich D. Is TSH a reliable indicator of thyroid hormone status in pregnancy? Horm Metab Res. 2022;54(07):435–441. doi:10.1055/a-1872-0246
3. Guo Y, Wei B, Dai W, Xie H. Establishment of trimester-specific reference intervals for thyroid stimulating hormone and free thyroxine during pregnancy in southwest China by indirect method. Ann Clin Biochem. 2022;59(4):234–241. doi:10.1177/00045632211063142
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