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Dosimetric evaluation and systematic review of radiation therapy techniques for early stage node-negative breast cancer treatment

Authors Chan TY, Tang JI, Tan PW, Roberts N

Received 2 May 2018

Accepted for publication 30 June 2018

Published 23 October 2018 Volume 2018:10 Pages 4853—4870

DOI https://doi.org/10.2147/CMAR.S172818

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Professor Nakshatri


Tabitha Y Chan,1 Johann I Tang,1 Poh Wee Tan,1 Neill Roberts2

1Department of Radiation Oncology, National University Cancer Institute, Singapore, Singapore; 2Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, UK

Abstract: Radiation therapy (RT) is essential in treating women with early stage breast cancer. Early stage node-negative breast cancer (ESNNBC) offers a good prognosis; hence, late effects of breast RT becomes increasingly important. Recent literature suggests a potential for an increase in cardiac and pulmonary events after RT. However, these studies have not taken into account the impact of newer and current RT techniques that are now available. Hence, this review aimed to evaluate the clinical evidence for each technique and determine the optimal radiation technique for ESNNBC treatment. Currently, six RT techniques are consistently used and studied: 1) prone positioning, 2) proton beam RT, 3) intensity-modulated RT, 4) breath-hold, 5) partial breast irradiation, and 6) intraoperative RT. These techniques show dosimetric promise. However, limited data on late cardiac and pulmonary events exist due to challenges in long-term follow-up. Moving forward, future studies are needed to validate the efficacy and clinical outcomes of these current techniques.

Keywords: early stage, breast cancer, radiation technique, dosimetric

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