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Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosis

Authors Al-Saeedi M, Al-Hajoj S

Received 20 June 2017

Accepted for publication 3 August 2017

Published 13 October 2017 Volume 2017:10 Pages 333—342

DOI https://doi.org/10.2147/IDR.S144446

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Sahil Khanna


Mashael Al-Saeedi, Sahal Al-Hajoj

Department of Infection and Immunity, Mycobacteriology Research Section, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

Abstract: Despite the efficacy of antibiotics to protect humankind against many deadly pathogens, such as Mycobacterium tuberculosis, nothing can prevent the emergence of drug-resistant strains. Several mechanisms facilitate drug resistance in M. tuberculosis including compensatory evolution, epistasis, clonal interference, cell wall integrity, efflux pumps, and target mimicry. In this study, we present recent findings relevant to these mechanisms, which can enable the discovery of new drug targets and subsequent development of novel drugs for treatment of drug-resistant M. tuberculosis.

Keywords: Mycobacterium tuberculosis, antibiotic resistance, compensatory evolution, epistasis, efflux pumps, fitness cost
 
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