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CUX2 functions as an oncogene in papillary thyroid cancer

Authors Sun Y, Ye D, Li Y, Chen E, Hao R, Cai Y, Wang Q, Wang O, Zhang X

Received 29 August 2018

Accepted for publication 22 November 2018

Published 24 December 2018 Volume 2019:12 Pages 217—224

DOI https://doi.org/10.2147/OTT.S185710

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Takuya Aoki


Yihan Sun,* Danrong Ye,* Yuefeng Li, Endong Chen, Rutian Hao, Yefeng Cai, Qingxuan Wang, Ouchen Wang, Xiaohua Zhang

Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 32500, China

*These authors contributed equally to this work

Background: In recent years, the incidence of thyroid cancer (TC), the most common endocrine malignancy, has been increasing. Emerging evidence indicates that the CUT/CUX/CDP family of proteins can play an important role in tumor development and progression by regulating many cancer-related functions. However, the molecular functions of CUX2 in TC remain unknown.
Methods: In this study, we used a series of loss-of-function experiments and Western blot analysis to investigate the function of CUX2 in TC and the mechanisms involved.
Results: Our data revealed that CUX2 expression levels were upregulated in papillary thyroid cancer (PTC). Functionally, CUX2 silencing significantly inhibited PTC cell line (KTC-1 and BCPAP) proliferation, colony formation, migration, invasion, and apoptosis. Furthermore, CUX2 induced epithelial–mesenchymal transition (EMT) and influenced the phosphorylation of AKT and mTOR in the PI3K–AKT–mTOR pathways.
Conclusion: In summary, CUX2 may function as a tumor promoter in TC.

Keywords: papillary thyroid carcinoma, CUX2, oncogene

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