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Current and Emerging Therapeutic Options for Hairy Cell Leukemia Variant

Authors Liu Q, Harris N, Epperla N, Andritsos LA

Received 1 December 2020

Accepted for publication 6 February 2021

Published 9 March 2021 Volume 2021:14 Pages 1797—1805

DOI https://doi.org/10.2147/OTT.S242247

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Gaetano Romano


Qiuying Liu,1 Nicholas Harris,1 Narendranath Epperla,2 Leslie A Andritsos1,3

1Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA; 2Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA; 3University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA

Correspondence: Leslie A Andritsos
University of New Mexico, 1201 Camino de Salud, Albuquerque, NM, 87102, USA
Tel +1-505-925-0405
Fax +1-505-925-0408
Email [email protected]

Abstract: Hairy cell leukemia variant (HCL-v) is a rare B-cell lymphoproliferative disorder with distinct immunophenotypic and molecular characteristics when compared to classical hairy cell leukemia (HCL-c). In contrast to the enormous progress in therapeutic options for HCL-c, HCL-v remains a therapeutic challenge due to inferior outcomes with standard chemoimmunotherapy and BCR signaling pathway inhibitors, and due to the fact that HCL-v has limited molecular therapeutic targets. In addition, because of the rarity of the disease, there is a paucity of later phase studies or multicenter trials to guide treatment decisions. In this article, we briefly review the diagnostic criteria and clinical characteristics of HCL-v and present a comprehensive overview of current therapeutic options in HCL-v.

Keywords: salvage therapy, rare lymphoid malignancies, HCL-v, HCL-c

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