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Clinical potential of nintedanib for the second-line treatment of advanced non-small-cell lung cancer: current evidence

Authors Rothschild S

Received 17 June 2014

Accepted for publication 12 August 2014

Published 1 September 2014 Volume 2014:5 Pages 51—57


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Pan-Chyr Yang

Sacha I Rothschild

Department of Internal Medicine, Medical Oncology, University Hospital Basel, Basel, Switzerland

Abstract: The therapeutic landscape in non-small-cell lung cancer (NSCLC) is changing. The description of molecular alterations leading to NSCLC carcinogenesis and progression (so-called oncogenic driver mutations) and the development of targeted agents interfering with the tumor-promoting intracellular signaling pathways have improved the outcome for many patients with advanced/metastatic NSCLC. However, many patients with stage IV NSCLC do not have one of the targetable predictive biomarkers, and are therefore in need of classical chemotherapy. This especially applies to squamous cell cancer. A platinum-based doublet chemotherapy is the standard of care for patients with stage IV NSCLC. As second-line therapies, docetaxel, pemetrexed, and the EGFR tyrosine-kinase inhibitor erlotinib have demonstrated benefit in Phase III randomized trials. Recently, the addition of the angiokinase inhibitor nintedanib to docetaxel has proven efficacious, and is a new treatment option in the second-line setting. Preclinical and clinical data of nintedanib for the treatment of lung cancer patients are reviewed here.

Keywords: nintedanib, lung cancer, angiokinase inhibitor, VEGFR, PDGF, FGFR

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