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Clinical Interventions in Aging

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ISSN: 1178-1998

Journal Articles:

Biomarker-Guided Clinical Interventions in Geriatric Heart Failure: From Phenotyping to Practice

Heart failure (HF) affects over 64 million people worldwide and disproportionately burdens adults aged 65 and above, in whom clinical presentation, comorbidity burden, and physiological reserve differ markedly from younger patients. In this population, guideline-directed medical therapies — including renin-angiotensin-aldosterone system inhibitors, beta-blockers, mineralocorticoid receptor antagonists, and SGLT2 inhibitors — produce variable effects on biomarkers of inflammation, neurohormonal activation, and cardiorenal stress, with evidence specific to older adults remaining limited. This Article Collection invites original research, systematic reviews, and narrative reviews examining how clinical interventions in older adults with HF influence biomarker profiles, phenotypic trajectories, and patient outcomes.