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Clinical features and treatment of maturity onset diabetes of the young (MODY)

Authors Gardner DS,Tai ES

Received 24 February 2012

Accepted for publication 1 March 2012

Published 1 May 2012 Volume 2012:5 Pages 101—108

DOI https://dx.doi.org/10.2147/DMSO.S23353

Review by Single-blind

Peer reviewer comments 2

Daphne SL Gardner1, E Shyong Tai2
1Department of Endocrinology, Singapore General Hospital, 2Department of Endocrinology, National University Hospital, Singapore

Abstract: Maturity onset diabetes of the young (MODY) is a heterogeneous group of disorders that result in ß-cell dysfunction. It is rare, accounting for just 1%–2% of all diabetes. It is often misdiagnosed as type 1 or type 2 diabetes, as it is often difficult to distinguish MODY from these two forms. However, diagnosis allows appropriate individualized care, depending on the genetic etiology, and allows prognostication in family members. In this review, we discuss features of the common causes of MODY, as well as the treatment and diagnosis of MODY.

Keywords: type 1 diabetes, type 2 diabetes, HNF1A, HNF4A, HNF1B, GCK

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