Back to Journals » Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy » Volume 5

Clinical features and treatment of maturity onset diabetes of the young (MODY)

Authors Gardner D, Tai ES

Received 24 February 2012

Accepted for publication 1 March 2012

Published 1 May 2012 Volume 2012:5 Pages 101—108

DOI https://doi.org/10.2147/DMSO.S23353

Review by Single-blind

Peer reviewer comments 2


Daphne SL Gardner1, E Shyong Tai2
1Department of Endocrinology, Singapore General Hospital, 2Department of Endocrinology, National University Hospital, Singapore

Abstract: Maturity onset diabetes of the young (MODY) is a heterogeneous group of disorders that result in ß-cell dysfunction. It is rare, accounting for just 1%–2% of all diabetes. It is often misdiagnosed as type 1 or type 2 diabetes, as it is often difficult to distinguish MODY from these two forms. However, diagnosis allows appropriate individualized care, depending on the genetic etiology, and allows prognostication in family members. In this review, we discuss features of the common causes of MODY, as well as the treatment and diagnosis of MODY.

Keywords: type 1 diabetes, type 2 diabetes, HNF1A, HNF4A, HNF1B, GCK

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]