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Clinical efficacy of computed tomography-guided iodine-125 seed implantation therapy in patients with advanced spinal metastatic tumors

Authors Zhang L, Lu J, Wang Z, Cheng Y, Teng G, Chen K

Received 29 August 2015

Accepted for publication 28 October 2015

Published 18 December 2015 Volume 2016:9 Pages 7—12

DOI https://doi.org/10.2147/OTT.S95410

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 2

Editor who approved publication: Dr William Cho


Liyun Zhang,1,2,* Jian Lu,2,* Zhongmin Wang,3 Yingsheng Cheng,4 Gaojun Teng,5 Kemin Chen4

1Medical College of Soochow University, Suzhou, 2Department of Radiology, Shanghai Ruijin Hospital Luwan Branch, 3Department of Radiology, Shanghai Ruijin Hospital, 4Department of Radiology, Shanghai the Sixth People Hospital, Shanghai, 5Department of Radiology, Jiangsu Key Laboratory of Molecular and Functional Imaging, Zhongda Hospital, Medical School, Southeast University, Nanjing, People’s Republic of China

*These authors contributed equally to this work


Objective: The purpose of this study was to examine the safety and clinical efficacy of computed tomography (CT)-guided radioactive iodine-125 (125I) seed implantation treatment in patients with spinal metastatic tumors.
Methods: We retrospectively analyzed 20 cases of spinal metastatic tumors, including nine men and eleven women aged 50–79 years (mean age: 61.1 years). We used treatment planning system (TPS) to construct three-dimensional images of the spinal metastatic tumors and to determine what number and dose rate distribution to use for the 125I seeds. The matched peripheral dose of the 125I seed implantation was 90–130 Gy. Twenty-four spinal metastatic tumors were treated by CT-guided radioactive 125I seed implantation. A median of 19 (range: 4–43) 125I seeds were implanted.
Results: Twenty cases were followed for a median of 15.3 months (range: 7–32 months). The rate of pain relief was 95%. The median control time for all of the patients was 12.5 months. The 3-, 6-, and 12-month cumulative local control rates were 100%, 95%, and 60%, respectively. The median survival time for all of the patients was 16 months. The cumulative 6- and 12-month survival rates were 100% and 78.81%, respectively. No major complications were observed. No 125I seeds were lost or migrated to other tissues or organs.
Conclusion: CT-guided radioactive 125I seed implantation is a safe, effective, and minimally invasive method for the treatment of patients with spinal metastatic tumors. It is a possible alternative therapy for the treatment of spinal metastases.

Keywords: spinal metastatic tumor, iodine isotopes, computed tomography guided, interventional treatment

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