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CircRNA_104565 Promoted Cell Proliferation in Papillary Thyroid Carcinoma by Sponging miR-134

Authors Gong J, Kong X, Qi J, Lu J, Yuan S, Wu M

Received 23 October 2020

Accepted for publication 11 December 2020

Published 18 January 2021 Volume 2021:14 Pages 179—185

DOI https://doi.org/10.2147/IJGM.S288360

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Jianming Gong,* Xiangdong Kong,* Jinhui Qi, Jiangkun Lu, Shaofeng Yuan, Ming Wu

Department of Surgery, Tinglin Hospital of Jinshan District, Shanghai 201505, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Ming Wu
Department of Surgery, Tinglin Hospital of Jinshan District, No. 80 Siping North Road, Jinshan District, Shanghai 201505, People’s Republic of China
Tel + 86-18121367005
Email wum7005@126.com

Background: Thyroid cancer is one of the most common cancers with rising incidence worldwide, and papillary thyroid carcinoma (PTC) accounts for 80– 85% of thyroid malignancy. Although it has been reported that many genes relate to the carcinogenesis of PTC, the molecular mechanisms remain mostly unclear.
Methods: QRT-PCR assay was performed to detect circRNA_104565, miR-134 and ELF2 expression. CCK8 assay was exercised to examine cell proliferation. Western blot was used to detect ELF2 expression.
Results: We found that circRNA_104565 was highly expressed in PTC tissue and cell and promoted cell proliferation in vitro and in vivo. In addition, circRNA_104565 promoted cell proliferation in PTC by regulating the miR-134/ELF2 axis.
Conclusion: Hence, revealing the function of circRNA_104565 in PTC is important for understanding the molecular mechanism of carcinogenesis and providing new biomarkers or therapeutic targets for PTC.

Keywords: circRNA_104565, cell proliferation, PTC, miR-134, ELF2

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