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Circadian rhythms and clocks in adipose tissues: current insights

Authors Kiehn JT, Koch CE, Walter M, Brod A, Oster H

Received 26 January 2017

Accepted for publication 9 March 2017

Published 4 April 2017 Volume 2017:7 Pages 7—17

DOI https://doi.org/10.2147/CPT.S116242

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Marc Hébert

Jana-Thabea Kiehn,* Christiane E Koch,* Marina Walter, Alexandra Brod, Henrik Oster

Chronophysiology Group, Medical Department I, University of Lübeck, Lübeck, Germany

*These authors contributed equally to this work

Abstract: Endogenous circadian timekeepers are found in most cells and organs of the body, including the different types of adipose tissues. This clock network orchestrates 24-hour rhythms of physiology and behavior to adapt the organism to daily recurring changes in the environment. Energy intake and expenditure as well as adipose physiology are under circadian control and, therefore, energy homeostasis and circadian clock function are closely linked. In this review, we summarize the current knowledge about the regulation and targets of adipocyte circadian clocks and how circadian rhythm disruption affects energy homeostasis and adipose tissue function. We provide a more detailed overview of metabolic phenotypes of different mouse models of circadian clock dysfunction and discuss the implications of (adipose) clock disruption on adipocyte–brain cross talk and metabolic homeostasis.

Keywords: food intake, metaflammation, clock genes, adipocyte–brain cross talk, adipokines

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