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Biological Function of HYOU1 in Tumors and Other Diseases

Authors Rao S, Oyang L, Liang J, Yi P, Han Y, Luo X, Xia L, Lin J, Tan S, Hu J, Wang H, Tang L, Pan Q, Tang Y, Zhou Y, Liao Q

Received 14 December 2020

Accepted for publication 15 February 2021

Published 5 March 2021 Volume 2021:14 Pages 1727—1735

DOI https://doi.org/10.2147/OTT.S297332

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Takuya Aoki


Shan Rao,1 Linda Oyang,1 Jiaxin Liang,1 Pin Yi,1 Yaqian Han,1 Xia Luo,1 Longzheng Xia,1 Jinguan Lin,1 Shiming Tan,1 Jiaqi Hu,1 Hui Wang,1 Lu Tang,1,2 Qing Pan,1,2 Yanyan Tang,1 Yujuan Zhou,1 Qianjin Liao1

1Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, People’s Republic of China; 2University of South China, Hengyang, 421001, Hunan, People’s Republic of China

Correspondence: Qianjin Liao; Yujuan Zhou
Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Changsha, 410013, Hunan, People’s Republic of China
Tel +86-731-88651681
Fax +86-731-88651999
Email [email protected]; [email protected]

Abstract: Various stimuli induce an unfolded protein response to endoplasmic reticulum stress, accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia-upregulated 1 gene (HYOU1) is a chaperone protein located in the endoplasmic reticulum. HYOU1 expression was upregulated in many diseases, including various cancers and endoplasmic reticulum stress-related diseases. HYOU1 does not only play an important protective role in the occurrence and development of tumors, but also is a potential therapeutic target for cancer. HYOU1 may also be used as an immune stimulation adjuvant because of its anti-tumor immune response, and a molecular target for therapy of many endoplasmic reticulum-related diseases. In this article, we summarize the updates in HYOU1 and discuss the potential therapeutic effects of HYOU1.

Keywords: HYOU1, tumor, endoplasmic reticulum, anti-tumor immunity

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