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Autologous chondrocyte implantation for cartilage repair: current perspectives

Authors Zellner J, Krutsch W, Pfeifer C, Koch M, Nerlich M, Angele P

Received 31 July 2015

Accepted for publication 3 October 2015

Published 11 November 2015 Volume 2015:7 Pages 149—158

DOI https://doi.org/10.2147/ORR.S65569

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Jiabing Fan

Peer reviewer comments 3

Editor who approved publication: Professor Clark Hung


Johannes Zellner,1 Werner Krutsch,1 Christian G Pfeifer,1 Matthias Koch,1 Michael Nerlich,1 Peter Angele1,2

1Department of Trauma Surgery, University Medical Center Regensburg, Regensburg, Germany; 2Sporthopaedicum, Regensburg, Germany

Abstract: Over the last decade, regenerative treatment options have become the more routinely used techniques for treatment of cartilage defects, with predictable outcomes for their specific indications. For large chondral lesions in young patients, in particular, autologous chondrocyte implantation is the treatment of choice for restoration of joint health. This review focuses on indications, results, and outcome predictors of autologous chondrocyte implantation in comparison to other regenerative treatment procedures and discusses improvement options and future perspectives for autologous chondrocyte transplantation. As research activities are increasing in the field of regenerative joint therapy, recent developments may help to overcome remaining limitations step by step.

Keywords: ACI, cartilage repair, matrix- associated autologous chondrocyte transplantation, microfracture, osteochondral transplantation

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