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Noteworthy comment: This paper is noteworthy in that it suggests that duloxetine represents a potentially important non-opioid therapy for knee osteoarthritis. This is of particular importance given physicians' struggles with treating osteoarthritic conditions while maintaining patient safety.

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Safety and efficacy of duloxetine in Japanese patients with chronic knee pain due to osteoarthritis: an open-label, long-term, Phase III extension study

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