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Analysis of Urinary Pathogen Cultures and Drug Sensitivity in Patients with Urinary Stones for Five Consecutive Years in Xiangya Hospital, China

Authors Bai Y, Liu Q, Gu J, Zhang X, Hu S

Received 4 December 2019

Accepted for publication 23 April 2020

Published 11 May 2020 Volume 2020:13 Pages 1357—1363

DOI https://doi.org/10.2147/IDR.S241036

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Eric Nulens


Yao Bai,1,2 Qingxia Liu,3 Jie Gu,1,4 Xiaobo Zhang,1 Sheng Hu1

1Xiangya International Medical Center, Department of Geriatrics Urology, Xiangya Hospital, Central South University, Changsha 410008, People’s Republic of China; 2Medizinische Klinik and Poliklinik IV, Klinikum Der Universität München, Munich, Germany; 3Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha 410008, People’s Republic of China; 4Martini-Klinik Prostate Cancer Center, Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany

Correspondence: Xiaobo Zhang
Xiangya International Medical Center, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, People’s Republic of China
Email zhangxb@csu.edu.cn
Sheng Hu
Xiangya International Medical Center, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, People’s Republic of China
Email 15574972213@163.com

Objective: To analyze pathogen distribution and drug sensitivity in patients with urinary calculi and thereby gain insight into the most appropriate antibacterial drugs for perioperative therapy.
Materials and Methods: From January 2014 to December 2018, the results of mid-stream urine pathogen culture and drug sensitivity tests were evaluated retrospectively for 353 patients with urinary calculi. SPSS software version 23.0 was used to analyze the data.
Results: A total of 353 strains of pathogens were isolated from urine culture. Among these, 278 (79%) strains belonged to the top 10 most frequently isolated pathogens, comprising 209 (75.2%) Gram-negative bacilli and 69 (24.8%) Gram-positive cocci. Escherichia coli was the most frequently isolated pathogen overall and the most frequently isolated Gram-negative bacillus, and Enterococcus faecalis was the most frequently isolated Gram-positive coccus. Drug sensitivity levels were effectively unchanged for less commonly used drugs, whereas drug resistance rates remained high for commonly used drugs such as ampicillin trihydrate, ampicillin/sulbactam, cefazolin, ceftriaxone, aztreonam, levofloxacin and ciprofloxacin.
Conclusion: E. coli and E. faecalis remain the most common Gram-negative bacillus and Gram-positive coccus uropathogens, respectively, in patients with urinary calculi. Mid-stream urine pathogen culture and drug sensitivity tests should be used to select appropriate antibacterial drugs before treatment, particularly for perioperative patients with urinary calculi.

Keywords: urine pathogen culture, drug sensitivity, urinary calculi, Escherichia coli, Enterococcus faecalis

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