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Acute vasoreactivity test results in severe pulmonary hypertension patients with chronic obstructive pulmonary disease: our experience with 29 cases

Authors Asker S, Asker M

Received 14 February 2015

Accepted for publication 1 April 2015

Published 28 May 2015 Volume 2015:10(1) Pages 969—973

DOI https://doi.org/10.2147/COPD.S82856

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Richard Russell

Selvi Asker,1 Muntecep Asker2

¹Department of Chest Diseases, Van Yuksek Ihtisas Training and Research Hospital, Van, Turkey; 2Department of Cardiology, Van Yuksek Ihtisas Training and Research Hospital, Van, Turkey

Aim: The aim of the current study is to evaluate acute vasoreactivity test (AVT) results in severe pulmonary hypertension patients with chronic obstructive pulmonary disease and to compare the demographical, clinical, and laboratory variables in positive and negative cases.
Methods: This retrospective, clinical study was performed on 29 cases in the departments of cardiology and chest diseases of our tertiary care center. AVT was positive in 12 (41.4%) cases and negative in 17 (58.6%) cases. Demographical variables, cardiopulmonary indicators, and laboratory findings were compared in these two subgroups.
Results: The mean age was 62.3±7.8 years for AVT negative group, while it was 64.8±7.3 years in AVT positive group (P=0.38). Except for the changes in systolic, diastolic, and mean pulmonary arterial pressures before and after iloprost administration, there were no statistically significant differences regarding any of the parameters under investigation in both groups.
Conclusion: Despite the high rate of positivity for AVT in severe pulmonary hypertension patients with chronic obstructive pulmonary disease, none of the variables under investigation displayed a noteworthy difference between AVT negative and positive groups. Identification of factors likely to influence AVT results is important for establishment of appropriate treatment protocols especially for AVT negative cases.

Keywords: chronic obstructive pulmonary disease, pulmonary hypertension, acute vasoreactivity test

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