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A Rare Case of Primary Signet-Ring Cell Cervical Carcinoma: Early Stage with Independent Bilateral Ovarian Metastases

Authors Li S, Gan F, Luo M, Luo P

Received 6 January 2021

Accepted for publication 24 February 2021

Published 23 March 2021 Volume 2021:14 Pages 2101—2107

DOI https://doi.org/10.2147/OTT.S300424

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Alberto Bongiovanni


Shiyun Li, Fuqiang Gan, Manling Luo, Puying Luo

Department of Gynecology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, Jiangxi, People’s Republic of China

Correspondence: Puying Luo
Department of Gynecology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, No. 152, Aiguo Road, Donghu District, Nanchang, Jiangxi, 330006, People’s Republic of China
Tel/Fax +86-0791-86897371
Email [email protected]

Background: Primary signet-ring cell carcinoma of the uterine cervix (PSRCCC) is defined as a mucinous carcinoma. PSRCCC with independent bilateral ovarian metastases has not been previously reported in the literature.
Case Presentation: Herein we describe a case of PSRCCC with ovarian involvement. The patient underwent a detailed complete physical examination, and surgery was then performed to resect all of the tumors. All tumors expressed human papillomavirus 18 no distant tumors were detected, and estrogen receptor and progesterone receptor testing were negative, suggesting that the cervix was the primary site.
Conclusion: This is the first report of a case of PSRCCC metastasis to bilateral ovaries only. Conservative management of human papillomavirus-associated type endocervical adenocarcinomas with independent ovarian metastases should be considered.

Keywords: conservative management, transtubal spread

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