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A High Incidence of Metabolic Syndrome Traits in Mexicans Points at Obesity-Related Metabolic Dysfunction

Authors Bello-Chavolla OY, Vargas-Vázquez A, Antonio-Villa NE, Del Razo-Olvera FM, Elías-López D, Aguilar-Salinas CA

Received 28 June 2020

Accepted for publication 11 December 2020

Published 9 March 2021 Volume 2021:14 Pages 1073—1082


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Ming-Hui Zou

Omar Yaxmehen Bello-Chavolla,1,2 Arsenio Vargas-Vázquez,1,3,* Neftali Eduardo Antonio-Villa,1,3,* Fabiola Mabel Del Razo-Olvera,1 Daniel Elías-López,1 Carlos A Aguilar-Salinas1,4,5 For the Metabolic Syndrome Study Group

1Unidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; 2Division of Research, Instituto Nacional de Geriatría, Mexico City, Mexico; 3MD/PhD (PECEM) Program, Facultad de Medicina, UNAM, Mexico City, Mexico; 4Division of Nutrition, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; 5Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico

*These authors contributed equally to this work

Correspondence: Carlos A Aguilar-Salinas
Unidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, Distrito Federal, CP 14080, México
Tel +525554870900, 5703
Email [email protected]

Introduction: Metabolic Syndrome (MS) is a construct relating to a series of metabolic dysfunctions attributable to insulin resistance and obesity. Here, we estimate the incidence of MS according to their individual components using a Mexican open-population cohort.
Methods: We evaluated data of 6144 Mexicans amongst whom 3340 did not have MS either by IDF or ATP-III definitions using data from an open-population cohort. We estimated the incidence of MS and each of its traits after a median follow-up of 2.24 (IQR 2.05– 2.58) years and evaluated risk factors for MS incidence and each of its traits. We also explored individuals without any MS trait to evaluate trait and MS incidence after follow-up.
Results: We observed a high incidence of MS-IDF (115.11 cases per 1000 person-years, 95% CI 107.76– 122.47), followed by MS-ATP-III (75.77 cases per 1000 person-years, 95% CI). The MS traits with the highest incidence were low HDL-C and abdominal obesity, which was consistent for subjects without MS and those without any MS trait. When assessing predictors of MS incidence, obesity, insulin resistance, and increased apolipoprotein B levels predicted MS incidence. Weight loss > 5% of body weight and physical activity were the main protective factors. Obesity was a main determinant for incident MS traits in our population, with weight loss being also a protective factor for most MS traits.
Conclusion: We observed a high incidence of MS in apparently healthy Mexican adults. Low HDL-C and abdominal obesity were the most frequent incident MS traits, with obesity being the main determinant of its incidence.

Keywords: metabolic syndrome, obesity, incidence, Mexicans, metabolic risk

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