Volumetric brain abnormalities in polysubstance use disorder patients
Authors Noyan CO, Kose S, Nurmedov S, Metin B, Darçın AE, Dilbaz N
Received 4 March 2016
Accepted for publication 12 April 2016
Published 13 June 2016 Volume 2016:12 Pages 1355—1363
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Lucy Goodman
Peer reviewer comments 2
Editor who approved publication: Dr Roger Pinder
Cemal Onur Noyan,1 Samet Kose,2 Serdar Nurmedov,3 Baris Metin,1 Aslı Enez Darcin,4 Nesrin Dilbaz1
1Department of Psychology, Uskudar University, Istanbul, Turkey; 2Department of Psychiatry and Behavioral Sciences Center for Neurobehavioral Research on Addictions, University of Texas Medical School, Houston, TX, USA; 3Acibadem Healthcare Group, 4Department of Psychiatry, Kanuni Sultan Suleyman Research and Training Hospital, Istanbul, Turkey
Aim: Polysubstance users represent the largest group of patients seeking treatment at addiction and rehabilitation clinics in Turkey. There is little knowledge about the structural brain abnormalities seen in polysubstance users. This study was conducted to examine the structural brain differences between polysubstance use disorder patients and healthy control subjects using voxel-based morphometry.
Methods: Forty-six male polysubstance use disorder patients in the early abstinence period and 30 healthy male controls underwent structural magnetic resonance imaging scans. Voxel-based morphometry analysis was performed to examine gray matter (GM) abnormality differences.
Results: Polysubstance use disorder patients displayed significantly smaller GM volume in the thalamus, temporal pole, superior frontal gyrus, cerebellum, gyrus rectus, occipital lobe, anterior cingulate cortex, superior temporal gyrus, and postcentral gyrus.
Conclusion: A widespread and smaller GM volume has been found at different regions of the frontal, temporal, occipital, and parietal lobes, cerebellum, and anterior cingulate cortex in polysubstance users.
Keywords: early abstinence, gray matter volume, polysubstance use disorders, voxel-based morphometry
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]