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Vitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures

Authors Narvaez J, Maldonado G, Guerrero R, Messina OD, Rios C

Received 3 March 2020

Accepted for publication 21 May 2020

Published 11 June 2020 Volume 2020:12 Pages 105—115


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Chuan-Ju Liu

Jemina Narvaez,1 Genessis Maldonado,1 Roberto Guerrero,1 Osvaldo Daniel Messina,2 Carlos Rios1

1Rheumatology Department, Espíritu Santo University, Guayaquil, Ecuador; 2Rheumatology Department, Hospital Cosme Argerich, Buenos Aires, Argentina

Correspondence: Genessis Maldonado Email

Introduction: Currently, approximately more than one billion people around the world are considered to have deficient levels of vitamin D. International consensus recommends vitamin D supplementation to high-risk patients (advanced age, osteoporosis, liver failure, malabsorption syndromes, etc.) and those with levels below 30 ng/mL. There are several vitamin D formulations and dosages available, including megadoses. At the moment, there is no consensus on the definition of megadoses. The purpose of this review is to define what is a megadose and analyze its effectiveness in bone metabolism, risk of fractures and falls.
Conclusion: The administration of doses higher than 100,000 IU of vitamin D is considered a megadose. It is evident that the use of megadoses increases serum concentrations of vitamin D; however, there has been no evidence of a decrease in the risk of falls, vertebral fractures or changes in bone mineral density.

Keywords: vitamin D, supplementation, falls, bone mineral density

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