Back to Journals » Drug Design, Development and Therapy » Volume 11

Vitamin D levels in systemic sclerosis patients: a meta-analysis

Authors An L, Sun M, Chen F, Li J

Received 26 June 2017

Accepted for publication 21 September 2017

Published 27 October 2017 Volume 2017:11 Pages 3119—3125


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Tuo Deng

Lin An, Ming-hui Sun, Feng Chen, Jin-ran Li

Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China

This study aimed to investigate the association between vitamin D and systemic sclerosis (SSc) by meta-analysis.
Methods: A comprehensive search was performed through June 12, 2017. Pooled standardized mean difference (SMD) was used to estimate the mean vitamin D difference between case and control groups (or between diffused- and limited-type SSc). Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were used to assess the impact of vitamin D level on clinical characteristics of SSc patients. All statistical analyses were performed using Revman 5.0 software.
Results: The search yielded six studies with a total of 554 SSc patients and 321 healthy controls. The meta-analysis showed that SSc patients suffered from decreased vitamin D levels (SMD =–8.72 ng/mL; 95% CI: –10.11 to –7.32) compared with healthy controls. The meta-analysis results of three studies with 240 SSc patients (93 diffused-type and 147 limited-type SSc patients) showed that diffused-type SSc patients exhibited lower vitamin D levels (SMD =–4.71 ng/mL; 95% CI: –8.98 to –0.44) compared with limited-type SSc patients. However, vitamin D level was not found to be associated with Rodnan score (SMD =–2.29 ng/mL, 95% CI: –8.49 to 3.91, P=0.47), systolic pulmonary pressure (SMD =–1.68 ng/mL, 95% CI: –10.79 to 7.43, P=0.72), gastrointestinal ulcer (RR =1.01, 95% CI: 0.53–1.93, P=0.98), or pulmonary involvement (RR =1.01, 95% CI: 0.36–2.86, P=0.99) in SSc patients.
Conclusion: SSc patients exhibited lower vitamin D levels compared with healthy controls. Vitamin D levels in diffused-type SSc patients were significantly lower than those in limited-type SSc patients. The severity of clinical features was not associated with the extent of vitamin D deficit. Therefore, we hypothesize that SSc patients, especially diffused type, have lower vitamin D levels, and that the decrease of vitamin D levels might not be an accelerating factor of SSc severity.

Keywords: vitamin D, systemic sclerosis, meta-analysis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]