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Very early onset and greater vulnerability in schizophrenia: A clinical and neuroimaging study

Authors Margari F, Presicci A, Petruzzelli MG, Ventura P, Di Cuonzo F, Palma M, Margari L

Published 8 August 2008 Volume 2008:4(4) Pages 825—830


Francesco Margari1, Anna Presicci2, Maria Giuseppina Petruzzelli1, Patrizia Ventura2, Franca Di Cuonzo3, Michele Palma3, Lucia Margari2

1Department of Neurologic and Psychiatry Sciences, Psychiatry Unit; 2Department of Neurologic and Psychiatry Sciences, Child Neuropsychiatry Unit; 3Department of Neurologic and Psychiatry Sciences, Neuroradiologic Unit, University of Bari, Italy

Abstract: Although schizophrenia has been diagnosed in children, this group of disorders has received too little attention in the clinical and research literature. Preliminary data suggest that early onset schizophrenia (EOS) and very early onset schizophrenia (VEOS) tend to have a worse outcome than adult onset schizophrenia, and seem to be related to a greater familial vulnerability, due to genetic, psychosocial, and environmental factors. Recently, advanced neuroimaging techniques have revealed structural and functional brain abnormalities in some cerebral areas. This paper reports on a case diagnosed as VEOS, with premorbid year-long psychopathological history. The patient showed atypical proton magnetic resonance spectroscopy findings, and normal brain and spine computer tomography and brain magnetic resonance images.

Keywords: very early onset schizophrenia, early onset schizophrenia, premorbid neurodevelopmental abnormalities, magnetic resonance spectroscopy

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