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Use of transcranial magnetic stimulation in the treatment of selected movement disorders

Authors Brown KE, Neva JL, Ledwell NM, Boyd L

Received 26 June 2014

Accepted for publication 1 September 2014

Published 4 December 2014 Volume 2014:4 Pages 133—151

DOI https://doi.org/10.2147/DNND.S70079

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Prof. Dr. Thomas Müller


Video abstract presented by Ms Katlyn Brown

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Katlyn E Brown,1 Jason L Neva,2 Noah MH Ledwell,1 Lara A Boyd1,2

1Graduate Program in Rehabilitation Science, 2Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

Abstract: Transcranial magnetic stimulation (TMS) is a valuable technique for assessing the underlying neurophysiology associated with various neuropathologies, and is a unique tool for establishing potential neural mechanisms responsible for disease progression. Recently, repetitive TMS (rTMS) has been advanced as a potential therapeutic technique to treat selected neurologic disorders. In healthy individuals, rTMS can induce changes in cortical excitability. Therefore, targeting specific cortical areas affected by movement disorders theoretically may alter symptomology. This review discusses the evidence for the efficacy of rTMS in Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis. It is hoped that gaining a more thorough understanding of the timing and parameters of rTMS in individuals with neurodegenerative disorders may advance both clinical care and research into the most effective uses of this technology.

Keywords: repetitive transcranial magnetic stimulation, selected movement disorders, treatment

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