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Use of Methylphenidate in Excessive Daytime Sleepiness in Alzheimer’s Patients Treated with Donepezil: Case Series

Authors Bidzan L, Bidzan M

Received 20 August 2020

Accepted for publication 13 October 2020

Published 6 November 2020 Volume 2020:16 Pages 2677—2680

DOI https://doi.org/10.2147/NDT.S277740

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder


Leszek Bidzan,1 Mariola Bidzan2

1Department of Developmental Psychiatry, Psychotic and Geriatric Disorders, Medical University of Gdansk, Gdansk, Poland; 2Institute of Psychology, University of Gdansk, Gdansk, Poland

Correspondence: Mariola Bidzan Email mariola.bidzan@ug.edu.pl

Abstract: Sleep disorders, inversion of sleep rhythm, excessive daytime sleepiness, and sleeplessness at night are common in Alzheimer’s disease (AD). Sleep disorders in AD have a diverse pathogenesis and their incidence increases as the disease progresses. Some publications indicate possible beneficial effects of methylphenidate on sleep. We presented two cases of patients with diagnosed AD accompanied by sleep disorders which had a significant impact on their functioning. The pathogenesis of sleep disorders was different in those two cases. In both case studies, the use of methylphenidate brought an immediate clinical effect, improving sleep at night and functioning during the day.

Keywords: sleep disorders, Alzheimer’s disease, treatment, methylphenidate

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