Back to Journals » Lung Cancer: Targets and Therapy » Volume 3

Update on biomarkers for the detection of lung cancer

Authors Jantus-Lewintre, Usó, Sanmartin, Camps C

Received 16 March 2012

Accepted for publication 18 April 2012

Published 12 June 2012 Volume 2012:3 Pages 21—29

DOI https://doi.org/10.2147/LCTT.S23424

Review by Single-blind

Peer reviewer comments 5


Eloisa Jantus-Lewintre,1 Marta Usó,1 Elena Sanmartín,1 Carlos Camps,1–3

1
Molecular Oncology Laboratory, Fundación para la Investigación del Hospital General Universitario, Valencia, Spain; 2Deparment of Medical Oncology, Consorcio Hospital General Universitario, Valencia, Spain; 3Department of Medicine, Universitat de València, Valencia, Spain

Abstract: Patients at risk for lung cancer may have subclinical disease for years before presentation. The diagnosis of this disease is primarily based on symptoms, and detection often occurs after curative intervention is no longer possible. At present, no lung cancer early-detection biomarker is clinically available. This study reviews the most recent advances in early detection and molecular diagnostic biomarkers for the detection of lung cancer. This review includes an overview of the various biological specimens and matrices in which these biomarkers could be analyzed, as well as the diverse strategies and approaches for identifying new biomarkers that are currently being explored. Several novel and attractive biomarker candidates for the early detection of lung cancer exist. A remarkable shift is taking place from research based on single markers to analyzing signatures that are more complex in order to take advantage of new high-throughput technologies. However, it is still necessary to validate the most promising markers and the standardization of procedures that will lead to specific clinical applications.

Keywords: biomarker, detection, lung cancer, diagnosis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]