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Understanding antibiotic resistance via outer membrane permeability

Authors Ghai I, Ghai S

Received 14 November 2017

Accepted for publication 21 December 2017

Published 11 April 2018 Volume 2018:11 Pages 523—530

DOI https://doi.org/10.2147/IDR.S156995

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Joachim Wink


Ishan Ghai,1,2 Shashank Ghai3

1School of Engineering and Life Sciences, Jacobs University, Bremen, Germany; 2Consultation Division, RSGBIOGEN, New Delhi, India; 3Leibniz University Hannover, Hannover, Germany

Abstract: Collective antibiotic drug resistance is a global threat, especially with respect to Gram-negative bacteria. The low permeability of the bacterial outer cell wall has been identified as a challenging barrier that prevents a sufficient antibiotic effect to be attained at low doses of the antibiotic. The Gram-negative bacterial cell envelope comprises an outer membrane that delimits the periplasm from the exterior milieu. The crucial mechanisms of antibiotic entry via outer membrane includes general diffusion porins (Omps) responsible for hydrophilic antibiotics and lipid-mediated pathway for hydrophobic antibiotics. The protein and lipid arrangements of the outer membrane have had a strong impact on the understanding of bacteria and their resistance to many types of antibiotics. Thus, one of the current challenges is effective interpretation at the molecular basis of the outer membrane permeability. This review attempts to develop a state of knowledge pertinent to Omps and their effective role in solute influx. Moreover, it aims toward further understanding and exploration of prospects to improve our knowledge of physicochemical limitations that direct the translocation of antibiotics via bacterial outer membrane.

Keywords: antibiotics, Gram-negative bacteria, drug-resistance, outer membrane proteins, porins, membrane permeability, influx
 

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