Back to Browse Journals » Neuropsychiatric Disease and Treatment » Volume 4 » Issue 6

Treatment options and patient perspectives in the management of fibromyalgia: future trends

Authors Kim Lawson

Published 5 December 2008 Volume 2008:4(6) Pages 1059—1071


Review by Single-blind

Peer reviewer comments 4

Kim Lawson

Biomedical Research Centre, Sheffield Hallam University, Faculty of Health and Wellbeing, Sheffield, UK

Abstract: Fibromyalgia (FM) is a common, complex, and difficult to treat chronic widespread pain disorder, which usually requires a multidisciplinary approach using both pharmacological and non-pharmacological (education and exercise) interventions. It is a condition of heightened generalized sensitization to sensory input presenting as a complex of symptoms including pain, sleep dysfunction, and fatigue, where the pathophysiology could include dysfunction of the central nervous system pain modulatory systems, dysfunction of the neuroendocrine system, and dysautonomia. A cyclic model of the pathophysiological processes is compatible with the interrelationship of primary symptoms and the array of postulated triggers associated with FM. Many of the molecular targets of current and emerging drugs used to treat FM have been focused to the management of discrete symptoms rather than the condition. Recently, drugs (eg, pregabalin, duloxetine, milnacipran, sodium oxybate) have been identified that demonstrate a multidimensional efficacy in this condition. Although the complexity of FM suggests that monotherapy, non-pharmacological or pharmacological, will not adequately address the condition, the outcomes from recent clinical trials are providing important clues for treatment guidelines, improved diagnosis, and condition-focused therapies.

Keywords: fibromyalgia, pain, sleep dysfunction, fatigue, exercise, pharmacological treatments

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 


Readers of this article also read:

Protective effect of gonadotropin-releasing hormone analog on the ovarian reserve in rats receiving cyclophosphamide treatment

Gui T, Yuan GW, Shen K, Cao DY, Yang JX, Wu M, Lang JH

OncoTargets and Therapy 2015, 8:661-667

Published Date: 23 March 2015

Peripheral nerve blocks versus general anesthesia for total knee replacement in elderly patients on the postoperative quality of recovery

Liu JL, Yuan WX, Wang XL, Royse CF, Gong MW, Zhao Y, Zhang H

Clinical Interventions in Aging 2014, 9:341-350

Published Date: 18 February 2014

Aripiprazole in the treatment of Huntington’s disease: a case series

Andrea Ciammola, Jenny Sassone, Clarissa Colciago, Niccolò E Mencacci, Barbara Poletti, et al

Neuropsychiatric Disease and Treatment 2009, 5:1-4

Published Date: 25 November 2008

Anxiolytics may promote locomotor function recovery in spinal cord injury patients

Pierre A Guertin

Neuropsychiatric Disease and Treatment 2008, 4:759-763

Published Date: 8 August 2008

Tiagabine: efficacy and safety in partial seizures – current status

Jürgen Bauer, Déirdre Cooper-Mahkorn

Neuropsychiatric Disease and Treatment 2008, 4:731-736

Published Date: 8 August 2008

Treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy

Stéphane Auvin

Neuropsychiatric Disease and Treatment 2007, 3:729-734

Published Date: 15 January 2008

Effects of psycho-educational training and stimulant medication on visual perceptual skills in children with attention deficit hyperactivity disorder

Antigone S Papavasiliou, Irene Nikaina, Ioanna Rizou, Stratos Alexandrou

Neuropsychiatric Disease and Treatment 2007, 3:949-954

Published Date: 15 January 2008

Towards a cognitive stimulation program using an errorless learning paradigm in amnestic mild cognitive impairment

Léonie Jean, Martine Simard, Robert van Reekum, Marie-Ève Bergeron

Neuropsychiatric Disease and Treatment 2007, 3:975-985

Published Date: 15 January 2008