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Trametes robiniophila Murr: a traditional Chinese medicine with potent anti-tumor effects

Authors Pan J, Yang C, Jiang Z, Huang J

Received 2 November 2018

Accepted for publication 14 January 2019

Published 14 February 2019 Volume 2019:11 Pages 1541—1549

DOI https://doi.org/10.2147/CMAR.S193174

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 4

Editor who approved publication: Dr Ahmet Emre Eskazan


Jun Pan,1,2 Chenghui Yang,1,2 Zhou Jiang,1,2 Jian Huang1,2

1Cancer Institute (Key Laboratory of Cancer Prevention & Intervention, National Ministry of Education; Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province), Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, P.R. China; 2Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, P.R. China

Abstract: Trametes robiniophila Murr also known as Huaier, one of the traditional Chinese medicines, has been shown an effective adjuvant of cancer therapy. Accumulating evidence suggests that the anti-cancer effects of Huaier can be briefly divided into two aspects: the direct effects on tumor cells and the indirect effects on immune cells. In vitro and in vivo experiment showed Huaier directly inhibited tumor cell proliferation, induced tumor cell death, prevented metastasis and interfered with angiogenesis via various signaling pathways. The immunomodulatory effect of Huaier is associated with enhancement of the number and function of CD4+ T cells and NK cells, regulation of the polarization and function of macrophages, and elevated secretion of immune stimulatory cytokines. In this review, the anti-cancer effects and combined treatments of Huaier with other anti-cancer therapies, and the underlying mechanisms are summarized and discussed.

Keywords: Huaier, cancer, anti-tumor therapy, traditional Chinese medicine, adjuvant

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