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The role of visfatin in cancer proliferation, angiogenesis, metastasis, drug resistance and clinical prognosis

Authors Lin TC

Received 26 December 2018

Accepted for publication 11 March 2019

Published 23 April 2019 Volume 2019:11 Pages 3481—3491

DOI https://doi.org/10.2147/CMAR.S199597

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Professor Lu-Zhe Sun


Tsung-Chieh Lin

Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan

Abstract: Visfatin, also known as nicotinamide phosphoribosyltransferase or pre-B-cell colony-enhancing factor (PBEF), is an adipocytokine secreted by adipocytes, macrophages and inflamed endothelial tissue. Related reports have indicated a positive correlation between the visfatin level and obesity and cancer risk. In addition to its original function, visfatin is multifunctional and plays critical roles in the promotion of several processes relevant to cancer progression including cancer cell proliferation, angiogenesis, metastasis and drug resistance. The relative expression of visfatin and the potential visfatin receptor on a pan-cancer scale was determined based on the transcriptome analysis data in The Cancer Genome Atlas. We further show the clinical association of its signaling axis with the survival of cancer patients, which reveals its prognostic power for specific cancer types. This review illustrates visfatin’s biological functions related to cancer progression and demonstrates its clinical significance in predicting outcomes of cancer patients.

Keywords: visfatin, cancer progression, clinical outcome

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