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The role of NMDAR antibody in the etiopathogenesis of schizophrenia

Authors Timucin D, Ozdemir O, Parlak M

Received 30 May 2016

Accepted for publication 28 July 2016

Published 13 September 2016 Volume 2016:12 Pages 2327—2332

DOI https://doi.org/10.2147/NDT.S113872

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder


Damla Timucin,1 Osman Ozdemir,2 Mehmet Parlak3

1Department of Psychiatry, University of Health Sciences, Van Training and Research Hospital, Van, 2Department of Psychiatry, 3Department of Microbiology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey

Abstract: Many authors have reported the presence of serum NMDAR antibodies in varying proportions of patients with schizophrenia; however, many others have not been able to confirm this. Because of the contradictory findings reported in various studies, more definitive research on this issue is required. Hence, we have investigated the NR1 subunit of NMDAR antibodies in patients with schizophrenia (n=49) and healthy controls (n=48). None of the investigated patients with schizophrenia and none of the healthy controls showed positive antibody against the NR1 subunit of the NMDAR. On the basis of this result, we conclude that the NR1 subunit of the NMDAR antibodies does not seem to have a role in schizophrenia.

Keywords: schizophrenia, N-acetyl d-aspartate receptor, glutamate, antibody

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