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The role of gene sculptor microRNAs in human precancerous lesions

Authors Wang RH, He LY, Zhou SH

Received 16 April 2018

Accepted for publication 18 June 2018

Published 10 September 2018 Volume 2018:11 Pages 5667—5675

DOI https://doi.org/10.2147/OTT.S171241

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Arseniy Yuzhalin


Ran-Hong Wang,1,2 Lan-Ying He,1 Shui-Hong Zhou1

1Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou City, People’s Republic of China; 2Department of Otolaryngology, The Third Hospital of Hangzhou City, Hangzhou City, People’s Republic of China

Abstract: MicroRNAs (miRNAs) are small noncoding RNAs. These noncoding RNAs regulate the expression of target genes and inhibit the translation of target proteins at the post-transcriptional level. miRNAs also play an important role in human health, from the development and differentiation of cells to the occurrence and progression of disorders such as cancer, cardiovascular diseases, and neurodegenerative diseases. Precancerous lesions are lesions prior to invasive carcinomas, and carcinogenesis is a very complicated process, which is multistage and the result of multigene synergy. miRNAs exert effects as both oncogenes and tumor suppressor genes by regulating target genes involved in signaling pathways. Hence, precancerous lesions are accompanied by relevant miRNA changes. Based on the morphology of miRNAs in vivo and the specificity of miRNA, various novel miRNA analysis methods have been developed, including reverse transcription quantitative PCR, enzyme analysis, molecular beacons, and deep sequencing. For example, in the laryngeal epithelial precancerous lesions, the data demonstrate that the expression of miR-10a-5p is downregulated and miR-484 is the most abundant miRNA in hepatic precancerous lesions. In this review, we discuss the functional roles of miRNAs in human precancerous lesions.

Keywords: miRNAs, precancerous lesions, therapy

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