The role of fluorescence diagnosis in clinical practice

Aleksander Sieroń,¹ Karolina Sieroń-Stołtny,¹ Aleksandra Kawczyk-Krupka,¹ Wojciech Latos,¹ Sebastian Kwiatek,¹ Dariusz Straszak,¹ Andrzej M Bugaj<sup>1,2

1</sup>Clinical Department of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Silesian Medical University, Bytom, ²College of Health, Beauty Care and Education, Poznan, Poland

Abstract: Fluorescence diagnosis is a fast, easy, noninvasive, selective, and sensitive diagnostic tool for estimation of treatment results in oncology. In clinical practice the use of photodynamic diagnosis is focused on five targets: detection for prevention of malignant transformation precancerous changes, detection of neoplasmatic tissue in the early stages for fast removal, prevention of expansion and detection of recurrence of the cancer, monitoring therapy, and the possibility of excluding neoplasmatic disease. In this article, selected applications of fluorescence diagnosis at the Center for Laser Diagnostics and Therapy in Bytom, Poland, for each of these targets are presented.

Keywords: autofluorescence, cancer, fluorescence, imaging, photodynamic diagnosis, photodynamic therapy